Slim Fizz

Slim Fizz is effervescent tablets for weight loss that have become popular in the UK since July 2015. The first reviews about Slim Fizz were published in the British tabloid Daily Mail. Due to the publication of Slim Fizz review in the very popular tabloid, thousands of obese men and women learned about new Slim Fizz diet pills in just a few days.

The readers of Daily Mail online-version have left more than 150 comments to Slim Fizz review and actively distributed information about these diet pills in the popular social networks (Facebook and Twitter as well).

Agiotage around the new weight loss product – Slim Fizz was caused by the fact that the author of the review claims that Slim Fizz provides incredibly rapid weight loss. In the Slim Fizz review published in Daily Mail, one can familiarize with a “success story”, as well as pictures of women “before” and “after” Slim Fizz use.

The author of the review claims that Slim Fizz tablets helped to reduce weight by 5lb in just 10 days. Pictures “before” and “after” using Slim Fizz (after weight loss program) demonstrate that the author of the Slim Fizz review really managed to lose weight significantly.

The manufacturer of Slim Fizz claims that this weight loss product helps to “lose” up to 15lb in just 3 months. Unfortunately, the manufacturer of Slim Fizz cannot guarantee that body weight will not increase again after the end of weight loss program.

How does Slim Fizz work?

slim-fizzSlim Fizz effervescent tablets include active substance Glucomannan (alternative name: konjac mannan). Glucomannan is a natural soluble fibre, which well absorbs moisture.

Under the influence of moisture, the amount of glucomannan fibers increases and they are transformed into high-viscosity jelly-like mass. Glucomannan is gradually transformed into jelly within a few minutes after contact with water.

Due to the ability of glucomannan to swell, to increase in volume and to expand in the stomach, it stimulates the feeling of satiety after the oral use.

The uniqueness of Slim Fizz tablets is in that they should be dissolved in water before using. The use of dissolved Slim Fizz tablets eliminates the probability that glucomannan dietary fibers will swell in the esophagus and cause suffocation.

Unlike other glucomannan-containing weight loss products, Slim Fizz works directly in the stomach and does not create potential risks to normal breathing.

The manufacturer of Slim Fizz states that this slimming product does not cause side effects. However, comments about the fact that discomfort in the stomach can occur after Slim Fizz use, can be found in the customers’ reviews.

The new Slim Fizz weight loss tablets are manufactured by the British company, On-Group Ltd. The key brand of this company is proto-col. Under the brand proto-col, different weight loss products such as Slim Fizz, Thermo-Lite, Carb-Lite, L-carnitine, Pure Arginine are promoted.

For several weeks, Slim Fizz effervescent slimming tablets were sold on Amazon. Potential buyers of weight loss products had the possibility to buy Slim Fizz online in the UK, U.S., Canada and other worldwide countries.

Obese Britons had the opportunity to choose “next day delivery” of Slim Fizz. However, less than a month after the start of retail sales, the access to Slim Fizz purchase on Amazon was limited.

The manufacturer of Slim Fizz asserts that due to high demand, the entire stock of Slim Fizz was quickly sold out. Herewith, On-Group Ltd continues to take orders for Slim Fizz tablets, but does not clarify delivery terms of this weight loss product.

It should be noted that Slim Fizz is not the only over the counter slimming product containing soluble dietary fibres – glucomannan.

At Canadian pharmacies, glucomannan-containing weight loss products are sold under the brands Fibre & Weight Balance, Slimit, Beslim Slimphin and many others. In the country you live, glucomannan tablets and capsules can be sold under other trade names.

If you decide to buy glucomannan or other weight loss product online, read the terms of payment and delivery before making the order.

Saxenda for weight loss

After Saxenda was approved for weight loss, its popularity began to grow rapidly all over the USA. Saxenda is so popular mostly because this is the only drugs, which is used in the USA for injectable weight loss therapy. All the rest FDA-approved drugs, available on the U.S. market in 2015, are used for oral weight loss therapy.

Saxenda injections are used for weight loss for several months only. Therefore, you can hardly find any positive or negative feedbacks about Saxenda yet. Clinical trials have demonstrated that Saxenda provides a significant weight loss only when used for a long time, within 1-2 years. Thus, the first real feedbacks about Saxenda will appear no sooner than in the beginning of 2016.

It should be noted that Saxenda price without insurance is ten times higher than the prices of other weight loss drugs. Hence, Saxenda weight loss drug will be unavailable for patients without healthcare insurance.

Those people, who want to achieve a significant result using Saxenda, must be ready to take this drug for several years.

• When using only Saxenda for weight loss, the cost of one year weight loss therapy will exceed $10 000 US.
• Insured Americans will have to spend a little more than $350 US per year for Saxenda drug.

Such high price of Saxenda without insurance makes the purchase of this weight loss drug impossible. Therefore, an overwhelming majority of obese Americans will be prescribed cheap anorectic drugs, which prices are much lower than of Saxenda.

Unlike the USA, where anorectic drugs are actively used for weight loss, in EU countries the sale of anorectic drugs (including Phentermine) is prohibited.

The appearance of new Saxenda drug provides new opportunity for overweight European people to lose weight. So it is possible that many Europeans with diagnosed overweight or obesity will want to get a healthcare insurance only to be able to use an innovative Saxenda drug for weight loss.

Today, you can buy Saxenda only in the USA. Saxenda drug is approved for weight loss in EU and UK. Hence, it is possible that in the end of 2015 or beginning of 2016, people can buy Saxenda in the UK and 28 EU Member States.

Saxenda injections are not available online yet. Therefore, it is almost impossible to buy Saxenda online right now. If you decide to buy Saxenda online and Saxenda price on online pharmacy is lower than Saxenda price set by the manufacturer, then you can be certain that such Saxenda purchase offer is a fraud.

Novo Nordisk is an exclusive distributor of Saxenda in 2015-2016. You may find current information on suppliers of Saxenda and other weight loss products in the next reviews.

Regimex Review

Regimex is an anorectic drug approved by the FDA as an obesity treatment in September 2010. In 2015, plastic bottles containing 100 round, pink Regimex diet pills are supplied at the US market.

Each Regimex diet pill contains 25mg or 50mg of anorectic agent – Benzphetamine (as Hydrochloride). The same doses of Benzphetamine are contained in Didrex diet pills that were sold in the USA for several decades.

Regimex is a generic version of Didrex. Correspondingly, just as Didrex, Regimex is sold at the US pharmacies by prescription.

• The manufacturer of Regimex medication is WraSer Pharmaceuticals.
• The owner of marketing authorization for Regimex in the USA is Mikart Pharma.

In late 2012, WraSer Pharma planned to launch retail sale of Regimex in the USA. However, American consumers of weight loss products had the opportunity to buy Regimex only in early 2013.

Regimex is used for weight loss in patients with BMI of 30 and higher. Regimex side effects are the same as that of other amphetamine-like anorectics, including Adipex (Phentermine).

There are no significant differences between Regimex (Benzphetamine) and Adipex (Phentermine). Both these weight loss drugs reduce hunger and help to control appetite.

REGIMEXThe only significant difference between Regimex and Adipex is the price. Adipex is one of the most expensive diet pills available at the US market. Thus, when choosing diet pills, obese Americans compare the price of Adipex and Regimex and then pay attention to the effectiveness and safety of these anorectics.

Before comparing Regimex price with the price of other anorectic medications, discuss with your doctor the optimal dose of Regimex and dose of other anorectics.

For example, the doctor may recommend taking Regimex 25mg pills three times per day or instead of Regimex may prescribe Adipex 37.5mg pills that are taken just once daily.

In this case, when comparing the price of anorectics, it is necessary to compare the price of an Adipex 37.5mg pill with the price of three Regimex 25mg pills.

Many US pharmacies provide the opportunity to buy Regimex (Benzphetamine) at a discount. To buy Regimex at discount price, it is necessary to get a coupon from the attending physician or print the coupon for Regimex on the Internet.

The manufacturer of Regimex claims that when buying these diet pills at a discount, the price of a Regimex 25mg package is no more than $15 US. If you want to buy Regimex without a prescription, you can find Benzphetamine-containing drugs on online pharmacies. Just as the US retailers, online pharmacies offer to buy Regimex at a discount (with or without the coupon).

Razin Review

Razin_arizaRazin is a trade name of diet pills available on Israeli market of weight loss products. The original name of Razin pills in Hebrew – רזין. In the production of Razin diet drug, Phentermine anorexigenic agent is used.

At Israeli pharmacies, people can buy Razin diet pills containing 15mg of active ingredient – Phentermine (in form of resinat). Other dosage strengths of Razin (Phentermine) are not produced and not sold.

Razin diet pills were included to Israel Drug Registry in June 1992. In August 2012, the marketing authorization for Razin (Phentermine) was extended until August 2022.

CTS Chemical Industries (part of CTS Group) is the manufacturers and distributor of Razin (Phentermine). This pharmaceutical company is the only Israeli supplier of Phentermine-containing pills in 2015.

• CTS supplies packages containing 30 diet pills of Razin 15mg (3 blisters x 10 Razin pills) to Israeli market.
• The color of original Razin (Phentermine) pills – orange-purple. The expiration date of Razin 15mg pills – 3 years.

In 2012, CTS published a leaflet for Razin (PDF), which said that these Phentermine-containing pills could be prescribed to adolescents over 12 years old for anti-obesity treatment.

In Israel, Razin (Phentermine) pills are approved for anti-obesity mono-therapy in patients over 16 years old. Therefore, we may assume that Razin (Phentermine) leaflet, published by CTS, has been focused on Israeli exporters of Phentermine.

In some other countries, Phentermine is actually used for a teenage obesity treatment in children over 12 years old. For instance, in the UK – Phentermine pills for teenage obesity treatment are sold under the brand name Ionamin, while in Australia – under the brand name Duromine.

Another distinctive feature of Razin (Phentermine) pills is that they were approved in Israel for the treatment of morbid obesity in patients with BMI 30 and higher.

Australia is one of a few countries, where Phentermine can be prescribed for overweight men and women with BMI over 25. In the UK, USA and many other countries, Phentermine pills can be prescribed for weight loss in pre-obese patients, whose BMI is 27 and higher.

In Israel, as well as in other countries, Phentermine (Razin) is approved for a short-term weight loss therapy, lasting for 12 weeks. The recommended dose of Razin – one diet pill per day.

One diet pill of Razin 15mg equals to one diet pill of Duromine 15mg (or Ionamin 15mg). If you want to buy Phentermine 15mg pills, but you do not know under what brands they are available in your town, then you can find information on different Phentermine-containing drugs in our reviews.

For more information on Razin, visit your physician, pharmacist, or check out other blogs dedicated to Phentermine-based diet drugs and online forums, where people discuss the obesity problem.

Fen-Phen and history of compensation

Fen-Phen is an informal name of a combination of two drugs used as a combined obesity treatment in the 90s of the last century. Fen-Phen name consists of the first letters of anorectic drugs – Fenfluramine (Fen-) and Phentermine (-Phen).

Each of these drugs was approved as a short-term monotherapy of obesity. However, in many US diet centers and obesity clinics, physicians recommended their patients to use Fenfluramine in combination with Phentermine.

Fen-PhenThe combination of Phentermine and Fenfluramine (Fen-Phen) provided more rapid weight loss than the use of each of these drugs separately. Very rapid weight loss was achieved by the fact that Fen-Phen has burnt fat deposits even without significant physical loads (during night sleep as well).

Many US physicians have known that long-term studies of Fen-Phen safety were not conducted. Thus, writing a prescription for Fen-Phen, they could suppose that such combination therapy of obesity can create potential health risks for obese men and women.

Phentermine is no longer used in conjunction with Fenfluramine after it was proven that Fenfluramine causes serious heart problems. In 1997, Fenfluramine was withdrawn from the US market because of the safety problems, while Phentermine is still used as an obesity treatment.

For all history of Phentermine use together with Fenfluramine, about six millions of obese Americans could get a prescription for Fen-Phen. After Fenfluramine manufacturer recognized that this drug could cause adverse cardiac events, he agreed to pay monetary compensations the buyers of this drug.

The manufacturer of Fenfluramine pills was American Home Products Corporation. Subsequently, American Home Products was renamed in Wyeth. In 2009, Wyeth was acquired by Pfizer company.

In 1999, American Home Products agreed to pay $ 3.75 billion those, who used Fenfluramine as an obesity monotherapy or in combination with Phentermine. A fund was created for the payment of monetary compensations; it has remained open for 16 years (1999 to 2015).

The consumers of Fenfluramine (including Fen-Phen), who were able to prove that Fenfluramine caused heart valve defects, received of $ 1.5 million from the fund.

Fenfluramine consumers, who have not experienced serious cardiovascular side effects, could receive from $ 30 to $ 60 for each prescription obtained for the purchase of Fenfluramine.

Tenuate Retard

Tenuate Retard is a name of diet pills popular among potential buyers of diet pills in Germany. Artegodan company is indicated as the manufacturer and German supplier of Tenuate Retard pills.

Tenuate RetardIn the early 2000s, the European license for Tenuate Retard pills was withdrawn and Artegodan stopped their supplies to Germany. However, 15 years after the discontinuation of Tenuate Retard retail sales in Germany, many obese Germans are still trying to find these diet pills on online pharmacies.

Simultaneously with the termination of the sale of Tenuate Retard pills, all Diethylpropion-containing drugs including Regenon and Regenon Retard were withdrawn from the German market.

One of the few countries, where anorexigenic weight loss products containing Diethylpropion are still sold, is South Korea. In the USA, the marketing status of Diethylpropion-containing drugs is still active.

However, because of huge competition among dozens of the manufacturers and suppliers of well-known and absolutely new anorexigenic drugs, Diethylpropion sales are gradually declining in the USA.

Therefore, it is not excluded that after 10-15 years, the prescription for Diethylpropion will not be prescribed to obese Americans and the information about this drug will only be available in Wikipedia.

In 2015, one of the absolute sale leaders at the US market is still Phentermine. Herewith, it should be noted that the market of alternative weight loss products in the USA is actively developing and more and more obese Americans choose innovative over-the-counter and prescription diet pills.

Saxenda Review

Saxenda is a new drug approved by the FDA as an obesity treatment in December 2014. The developer of new anti-obesity drug – Saxenda is a multinational pharmaceutical company Novo Nordisk.

Just two months after Saxenda approval in the USA, this drug was approved as an obesity treatment in Canada, and after three months – in the EU. Despite the fact that new weight loss drug – Saxenda has already been approved in the Europe, USA and Canada, today one can buy Saxenda only in the USA.

Novo Nordisk announced the launch of Saxenda sales in late April 2015. In the next few months, the start of Saxenda sales in Canada and EU member states, as well as Saxenda approval for the obesity treatment in other regions of the world can be announced.

novo-nordiskOver the past 3 years, a few new weight loss drugs were approved in the USA, such as Contrave, Belviq and Qsymia. However, unlike these new anti-obesity drugs used for oral anti-obesity therapy, Saxenda is produced in solution for subcutaneous injections.

Since April 22, 2015, one can buy multi-dose prefilled pens containing 3ml of Saxenda solution at the US pharmacies. Each milliliter of Saxenda solution contains 6mg of active substance Liraglutide.

Thus, the dosage of active ingredient Liraglutide in a multi-dose pen is 18mg.

Each pre-filled syringe-pen has a convenient dosing device, which allows administering single doses:

• Saxenda (Liraglutide) 0.6mg
• Saxenda (Liraglutide) 1.2mg
• Saxenda (Liraglutide) 1.8mg
• Saxenda (Liraglutide) 2.4mg
• Saxenda (Liraglutide) 3.0mg

How does Saxenda work?

An exact mechanism of Saxenda action is not known. The developers of Saxenda drug assume that active ingredient Liraglutide stimulates the areas of the brain that regulate hunger and saturation.

Affecting the brain functions, Liraglutide decreases appetite and helps to increase saturation even after consuming a small amount of food.

The advantage of Liraglutide injectable drug over oral anorectics is that it significantly reduces the risk of type 2 diabetes.

Analysis of clinical trials has demonstrated that in regular use of Saxenda (Liraglutide) injectable anti-obesity drug within 3 months, the risk of type 2 diabetes decreases by approximately 80%.

It should be noted that Liraglutide anorectic agent is not similar to amphetamine-like anorectic, Phentermine. Therefore, mechanism of action and side effects of Saxenda (Liraglutide) differ from the mechanism of action and side effects of Phentermine-containing drugs.

Information on other features of innovative Saxenda anorectic you can find in the next reviews. If you are already using Saxenda, you can leave your review about this weight loss drug right now.

Saxenda contraindications

The list of Saxenda contraindications includes just a few diseases and conditions. Saxenda slimming drug should not be prescribed to overweight and obese men and women with:

• multiple endocrine neoplasia type 2 (MEN 2)
• medullary thyroid cancer (MTC) or family history of MTC
• allergy to anorexigenic agent – Liraglutide or inactive ingredients of Saxenda.

Children, adolescents under 18 years and pregnant women did not participate in clinical trials of Saxenda. Therefore, these groups of patients should be prescribed with alternative drugs for the obesity treatment instead of Saxenda.

Besides the list of contraindications, Product Monograph (Highlights of Prescribing Information) for Saxenda includes the list of cautions.

Saxenda cautions

Saxenda injections should not be prescribed to patients, who are taking or planning to take other drugs included in the pharmacological group of glucagon-like peptide-1 (GLP-1) receptor agonists, such as:

• Albiglutide (Eperzan)
• Dulaglutide (Trulicity)
• Lixisenatide (Lyxumia)
• Exenatide (Bydureon, Byetta)

Moreover, Saxenda should not be used in the combination with insulin and other prescription or over-the-counter weight loss products.

saxendaIf inflammation of pancreas occurred and pancreatitis was diagnosed during medical therapy of obesity, Saxenda use should be stopped. The main symptom of pancreatitis is severe abdominal pain.

Saxenda can cause a significant reduction of blood sugar level. Therefore, after the monitoring of blood glucose parameters, diabetic patients taking Saxenda may require the adjustment of daily doses of hypoglycemic drugs.

Some patients using Saxenda may develop gallstone disease. Data of clinical studies is insufficient to claim that gallstone disease is caused by Saxenda.

Nevertheless, if problems with gall bladder or bile ducts occur, it is necessary to stop using Saxenda and diagnose the cause of gallstone disease symptoms.

During clinical studies, it was recorded individual cases of thyroid cancer. However, a causal relationship between Saxenda use and thyroid cancer was not established. Nevertheless, the signs of thyroid cancer require an immediate cancellation of Saxenda. The main signs of thyroid cancer are increase in the size and mass of the neck, hoarseness, reduction in the frequency and depth of breathing, inflammation of the esophagus.

Saxenda may cause a slight increase in heart rate. Thus, obese patients with tachycardia require a regular monitoring of heart rate after the start of Saxenda use.

Saxenda can affect kidney functions. Therefore, patients with renal insufficiency should take Saxenda with caution.

In 0.2 % obese patients, treated with Saxenda during clinical studies, had suicidal thoughts and signs of depression. If unusual behavior or signs of anxiety disorder are observed after the start of Saxenda use, be sure to inform your treating physician.

Is Meridia better than Phentermine?

Meridia diet pills came into the market at the end of 90s of last century. More than 15 years ago, many experts believed that Meridia is much safer than Phentermine-containing drugs and Phentermine era comes to the end.

For hundreds of thousands of patients, Meridia drug was really better than Phentermine. However, statements that Meridia is safer than Phentermine proved premature.

meridiaThirteen years after the start of Meridia retail sales, researchers paid attention to the fact that long-term cardiovascular side effects develop in obese people using Meridia.

Compared to Phentermine side effects, cardiovascular side effects of Meridia posed a more serious danger to human health. Therefore, despite the fact that serious cardiovascular pathologies were diagnosed only in a few people used Meridia, this drug was recognized unsafe and its sale was terminated.

During the whole period of retail sales of Meridia, this drug was better choice for obese people who had contraindications to Phentermine and other amphetamine-like appetite suppressants.

After Meridia withdrawal from the US market, only amphetamine-like weight loss products for appetite control were sold at the U.S. pharmacies. Therefore, after the cessation of Meridia sales, access to medical appetite suppressant therapy was limited to tens of thousands of obese Americans.

Between 2010 and 2012, only amphetamines were used to control appetite in the USA. In June 2012, the FDA approved a new weight loss drug – Lorcaserin, which is not an amphetamine-like.

Thus, obese Americans who had contraindications to Phentermine again have the opportunity to conduct an intensive obesity therapy not only by means of a healthy diet and physical exercises, but also by means of appetite suppressant.

Just as 15 years ago, today the opinion is expressed that Lorcaserin is better than Phentermine and less often causes side effects. However, Phentermine always has a distinct advantage is that it is used for the obesity treatment for more than 50 years.

Therefore, all potential risks of Phentermine are well studied, the body’s reaction to the change of Phentermine dose is predictable, but the health benefits of an obese person is undeniable.

Mazanor Update (20.08.2015)

mazanorIn December 2006, Mazanor 1mg tablets were approved as an obesity treatment in South Korea. The supplier of Mazanor (Mazindol) at South Korean market of anorectic products is Kwang Dong Pharmaceutical.

Mazanor 1mg tablets are supplied in packs of 30 and 100 pieces each. Three tablets is the maximum daily dose of Mazanor. Therefore, when used regularly the maximum daily dose of Mazanor 3mg, 90 Mazanor 1mg tablets are needed for a month of anti-obesity therapy.

Obese Koreans with BMI of 30 and above can get a prescription for Mazanor. If BMI ranges from 27 to 29.9, South Korean doctors prescribe other anorectic drugs, such as Phentermine or Phendimetrazine.