Razin Review

Razin_arizaRazin is a trade name of diet pills available on Israeli market of weight loss products. The original name of Razin pills in Hebrew – רזין. In the production of Razin diet drug, Phentermine anorexigenic agent is used.

At Israeli pharmacies, people can buy Razin diet pills containing 15mg of active ingredient – Phentermine (in form of resinat). Other dosage strengths of Razin (Phentermine) are not produced and not sold.

Razin diet pills were included to Israel Drug Registry in June 1992. In August 2012, the marketing authorization for Razin (Phentermine) was extended until August 2022.

CTS Chemical Industries (part of CTS Group) is the manufacturers and distributor of Razin (Phentermine). This pharmaceutical company is the only Israeli supplier of Phentermine-containing pills in 2015.

• CTS supplies packages containing 30 diet pills of Razin 15mg (3 blisters x 10 Razin pills) to Israeli market.
• The color of original Razin (Phentermine) pills – orange-purple. The expiration date of Razin 15mg pills – 3 years.

In 2012, CTS published a leaflet for Razin (PDF), which said that these Phentermine-containing pills could be prescribed to adolescents over 12 years old for anti-obesity treatment.

In Israel, Razin (Phentermine) pills are approved for anti-obesity mono-therapy in patients over 16 years old. Therefore, we may assume that Razin (Phentermine) leaflet, published by CTS, has been focused on Israeli exporters of Phentermine.

In some other countries, Phentermine is actually used for a teenage obesity treatment in children over 12 years old. For instance, in the UK – Phentermine pills for teenage obesity treatment are sold under the brand name Ionamin, while in Australia – under the brand name Duromine.

Another distinctive feature of Razin (Phentermine) pills is that they were approved in Israel for the treatment of morbid obesity in patients with BMI 30 and higher.

Australia is one of a few countries, where Phentermine can be prescribed for overweight men and women with BMI over 25. In the UK, USA and many other countries, Phentermine pills can be prescribed for weight loss in pre-obese patients, whose BMI is 27 and higher.

In Israel, as well as in other countries, Phentermine (Razin) is approved for a short-term weight loss therapy, lasting for 12 weeks. The recommended dose of Razin – one diet pill per day.

One diet pill of Razin 15mg equals to one diet pill of Duromine 15mg (or Ionamin 15mg). If you want to buy Phentermine 15mg pills, but you do not know under what brands they are available in your town, then you can find information on different Phentermine-containing drugs in our reviews.

For more information on Razin, visit your physician, pharmacist, or check out other blogs dedicated to Phentermine-based diet drugs and online forums, where people discuss the obesity problem.

Phentermine influence on making decisions

In 2015, a resident of Florida (the USA) purchased a two-storey house at auction and paid for it a little more than $100,000. The initial price of this house at auction was $290,000.

Within a few days, this woman was sure that she bought two-storey house at very low price. However, in just a few days after the buying of house, she was shocked by the news that in addition to $ 100,000, she needs to pay Chase Mortgage charge of $400,000.

woman.mortgage.house_After careful study of conditions of house purchase, the woman tried to cancel the deal in court. The main motive for the deal termination was the fact that the woman began taking Phentermine pills shortly before the house purchase.

The woman claims that Phentermine pills negatively affect her ability to make informed decisions. However, the organizers of the auction claim that the house was sold properly, so there are no objective reasons for the deal cancellation.

Phentermine really can cause psychiatric side effects. However, it is almost impossible to prove that the therapeutic doses of Phentermine forced the woman to make uninformed decisions.

The list of Phentermine side effects includes several severe CNS side effects, such as clumsiness, confusion, dizziness, dysphoria, euphoria, headache, insomnia, overstimulation, psychosis, restlessness, tiredness, and tremor.

Unfortunately, the woman purchased the house has no convincing evidence that the decision was made under the Phentermine influence. Therefore, the chances to cancel the deal of buying a home are equal to zero.

In the USA, Phentermine is taken by hundreds of thousands of obese men and women. Therefore, the story of buying a home in the USA is not the only curious case related to the use of Phentermine anorectic.

Other unsuccessful examples, as well as success stories associated with Phentermine use can be found in the previous and the next reviews.

Saxenda side effects

Saxenda is a synthetic weight loss drug, which can cause a few types of side effects including gastrointestinal, cardiometabolic and psychiatric ones.

About 10% of patients involved in clinical trials were forced to stop using Saxenda because of pronounced side effects. The most common reasons for Saxenda cancellation because of side effects were severe nausea, vomiting and diarrhea.

doctor talking to her male patient at office

These side effects are mild or do not arise at all in the vast majority of people. Thus, the risk of side effects does not exceed the potential benefits of Saxenda to the health of obese patients.

Besides the listed gastrointestinal side effects, Saxenda can cause heartburn, constipation, abdominal pain, dry mouth, indigestion, belching, excessive accumulation of gas in the intestines, bloating, headache, dizziness, anxiety and insomnia.

Because of Saxenda ability to cause a large number of gastrointestinal side effects, patients with gastrointestinal diseases should use it with caution.

Not all Saxenda side effects are listed in this review. A full list of Saxenda side effects can be found in:

• Product Monograph for Saxenda – approved by Health Canada.
• Summary of Product Characteristics for Saxenda – approved by EMA.
• Highlights of Prescribing Information for Saxenda – approved by FDA.

It should be noted that obese people with low income and without insurance are not able to buy Saxenda. The cost of the obesity treatment for a month by means of Saxenda exceeds $1.000. Therefore, tens of millions of uninsured obese Americans do not have the possibility to use this drug for weight loss.

Price of Saxenda will decrease only when the first Saxenda generic drugs will appear at the international market.

However, given the fact that the first Saxenda generic drugs will appear after more than 10 years in developed countries, only those people who today do not pay enough attention to their body weight and timely do not take steps to prevent obesity and fight excess weight will be able to buy cheap Saxenda.

Because of the high price of Saxenda new drug, the vast majority of obese people will still choose oral therapy of obesity. Herewith, current trends show that more and more number of obese inhabitants of developed countries pay a special attention to safe obesity treatment.

Thus, sales of over-the-counter weight loss products grow as intensively as the sales of powerful prescription anorectics that can cause many potentially dangerous side effects.

Saxenda contraindications

The list of Saxenda contraindications includes just a few diseases and conditions. Saxenda slimming drug should not be prescribed to overweight and obese men and women with:

• multiple endocrine neoplasia type 2 (MEN 2)
• medullary thyroid cancer (MTC) or family history of MTC
• allergy to anorexigenic agent – Liraglutide or inactive ingredients of Saxenda.

Children, adolescents under 18 years and pregnant women did not participate in clinical trials of Saxenda. Therefore, these groups of patients should be prescribed with alternative drugs for the obesity treatment instead of Saxenda.

Besides the list of contraindications, Product Monograph (Highlights of Prescribing Information) for Saxenda includes the list of cautions.

Saxenda cautions

Saxenda injections should not be prescribed to patients, who are taking or planning to take other drugs included in the pharmacological group of glucagon-like peptide-1 (GLP-1) receptor agonists, such as:

• Albiglutide (Eperzan)
• Dulaglutide (Trulicity)
• Lixisenatide (Lyxumia)
• Exenatide (Bydureon, Byetta)

Moreover, Saxenda should not be used in the combination with insulin and other prescription or over-the-counter weight loss products.

saxendaIf inflammation of pancreas occurred and pancreatitis was diagnosed during medical therapy of obesity, Saxenda use should be stopped. The main symptom of pancreatitis is severe abdominal pain.

Saxenda can cause a significant reduction of blood sugar level. Therefore, after the monitoring of blood glucose parameters, diabetic patients taking Saxenda may require the adjustment of daily doses of hypoglycemic drugs.

Some patients using Saxenda may develop gallstone disease. Data of clinical studies is insufficient to claim that gallstone disease is caused by Saxenda.

Nevertheless, if problems with gall bladder or bile ducts occur, it is necessary to stop using Saxenda and diagnose the cause of gallstone disease symptoms.

During clinical studies, it was recorded individual cases of thyroid cancer. However, a causal relationship between Saxenda use and thyroid cancer was not established. Nevertheless, the signs of thyroid cancer require an immediate cancellation of Saxenda. The main signs of thyroid cancer are increase in the size and mass of the neck, hoarseness, reduction in the frequency and depth of breathing, inflammation of the esophagus.

Saxenda may cause a slight increase in heart rate. Thus, obese patients with tachycardia require a regular monitoring of heart rate after the start of Saxenda use.

Saxenda can affect kidney functions. Therefore, patients with renal insufficiency should take Saxenda with caution.

In 0.2 % obese patients, treated with Saxenda during clinical studies, had suicidal thoughts and signs of depression. If unusual behavior or signs of anxiety disorder are observed after the start of Saxenda use, be sure to inform your treating physician.

Movement without pain

Regular physical loads are as important for weight loss as healthy diet and maintenance of normal metabolism. However, people predisposed to obesity face serious problem, which significantly restricts their physical activity.

This problem is that joints experience excessive load because of extra pounds. Herewith, intensive physical loads aggravate joint problems.

foot+painIf there is no discomfort in the joints before workouts in the gym, regular jogging or biking; after the start of workouts – nagging pain can force you to reduce the intensity of physical exercises or to refuse from them at all.

The lack of physical activity significantly reduces the efficiency of fighting excess weight. Therefore, trying to lose weight, do not forget that joints require additional protection when increasing physical loads.

Without reliable protection of joints, aching joint pain, which previously occurred only when walking or performing exercise, will occur at rest.

In this case, any physical loads should be stopped, but to restore the function of joint tissue – a long time is required.

So that the joints maintain their mobility, as well as are not destroyed by intensive exercise, joint and connective tissue should be nourished with the glucosamine and chondroitin.

Glucosamine and chondroitin are building components of cartilage tissue that inhibit the development of degenerative processes in the joints and restore their function.

Therefore planning physical activities that stimulate rapid fat burning, be sure not to forget about the health of joints. After all, weight loss should be not only rapid, but also safe.

Otherwise, after solving the problem of excess weight, solution of the problem with aching and inflamed joints will be required.

Duromine effects on pregnancy

About 80% of pregnant women take medications that can cross the placenta and affect the fetal development. Some medications are prescribed during pregnancy to stimulate a normal fetal development. However, majority of medicines used during pregnancy are necessary to maintain the health of the pregnant woman.

Medications that have a negative effect on the fetal development are contraindicated during pregnancy. However, only in individual cases, the use of potentially dangerous medications during pregnancy is allowed. Herewith, medical therapy is conducted under the constant supervision of the treating doctor.

Duromine effects on pregnancy

Duromine is one of the few medications, which is contraindicated in pregnant women, however in rare cases it is used during pregnancy.

Pregnant women take Duromine only in the cases if overweight or obesity creates serious risks for their health or fetal health.

According to the Australian classification of potential risks to pregnant women, Duromine is included in B2 category. In the USA, Phentermine-containing medications are included in X category.

It should be noted that at various stages of pregnancy, Duromine has different risks to the fetus.

Duromine poses the greatest risk to the fetus in the first trimester of pregnancy when embryonic cells are actively dividing, and physiological systems and organs are formed and rapidly developed.

  • During the embryonic period, Duromine can cause birth defects that are the main cause of infant mortality in Australia and other developed countries.
  • After the end of the embryonic period, Duromine may cause developmental delay and functional immaturity of the fetal organs.

Potential risks of Duromine for mother and fetus depend both on the pregnancy trimester and on the dose used. The higher Duromine dose is, the higher the risk of disruption of the normal development of the fetus.

Herewith, the use of the maximum daily dose of Duromine between fertilization and implantation of the egg can cause miscarriage.

Women of childbearing age using Duromine should remember that during the first two-three weeks after conception they might not know about their pregnancy.

Therefore, in order to prevent the birth of a child with congenital defects, sexually active women should:

  • Take a pregnancy test and verify the absence of pregnancy before using Duromine.
  • Use reliable contraceptive methods during Duromine use.

If before the drug therapy of obesity, the test confirmed pregnancy, you should discuss with your doctor the possibility of using over-the-counter weight loss supplements, absolutely safe for the health of the mother and unborn child.

Obesity risk factors

Modern society created a stereotype on that a sedentary life is the key problem of obesity. However, many experts draw our attention to the fact that the obesity rate has sharply increased over the last 30 years. Still, the levels of physical activity almost have not changed.

Thus, the statement that the waist size increases due to low physical activity is unreliable. The thing is that a well-balanced diet helps to keep a beautiful body shape even if a person does not do fitness or sports.

Well, malnutrition and insufficient physical activity are not the only reasons why people become obese; there is one more – stress.

Over the decades, American researchers had been watching over teenagers and concluded that children prone to stress had higher risk of obesity than children who were raised in harmony and a healthy emotional atmosphere.

The researchers name several stressful situations that may cause obesity in teenagers.

• The psychological risk factors of weight gain in girls may be a stress caused by unstable financial situation in the family or parents’ divorce.

• It is believed that stress caused by serious problem of mother’s health one of the psychogenic risk factors of obesity in boys.

Despite the fact that the causes of obesity in children and adults may differ, the method of anti-obesity treatment slightly depends on a person’s age.

1. The first step towards weight loss in children and adults – is a gradual increase of physical activity.
2. The second step to weight loss – is a gradual elimination of fast food and high-calorie fatty food from daily diet.

If the body weight is reduced by less than 5% of the initial weight in three months after the anti-obesity treatment, people can make the third step towards a significant weight loss.

To lose weight rapidly, people can use diet pills, medical devices or surgery. But in most cases, people use diet pills to cure obesity at home.

Obesity risk factorsTo buy the most effective diet pills – you need a prescription. It has to be noted that highly effective anti-obesity drugs are only prescribed to those people, who has the appropriate indications for use of these drugs.

In the USA, Phentermine pills were the best diet pills over the last 50 years. These diet pills have been successfully used for weight loss for many decades. Therefore, their effectiveness was confirmed during the numerous clinical studies and thousands real reviews on Phentermine ability to stimulate the quick weight loss.

You can find both positive and negative feedbacks about Phentermine on the Internet forums. The main drawback of Phentermine pills is that their efficiency starts to decrease over a couple of months after the beginning of the treatment. Therefore, those people who did not manage to lose weight by means of Phentermine within 2-3 months, have to search some new methods to fight obesity.

If Phentermine pills are ineffective, you can always replace them by other diet pills that are available over-the-counter or by prescription only at pharmacies. Please note that over-the-counter weight loss supplements are less effective than Phentermine.

However, unlike Phentermine that can cause drug dependence and severe cardiovascular side effects, over-the-counter weight loss products are completely safe for human health.

In 2015, Phentermine pills are used for the treatment of obesity only in a few countries of the world. The highest volume of retail sales of Phentermine was registered in the USA. In addition, Phentermine pills are the leaders on the Australian market of weight loss products.

Some international distributors of weight loss products offer to buy Phentermine online in any country of the globe. When buying Phentermine online, a purchaser must know that the wholesale and retail sales of Phentermine without prescription – are illegal.

Herewith, only those Companies can import Phentermine to the USA or Australia, which own the marketing authorization for Phentermine in these countries.

Obesity and plastic surgery

In 2015, the research data demonstrated that obesity negatively affects the recovery period after plastic surgery.

The study was to monitor patients who use liposuction or abdominoplasty for weight loss. The researchers concluded that more than 7% of obese patients have had some postoperative complications within 1 month after the plastic surgery. Herewith, more than 3% of obese people required hospitalization due to complications.

Despite the high risks of complications, hundreds of thousands of obese people annually choose namely surgery for weight loss. The advantage of surgery over pharmacotherapy and non-pharmacological treatment of obesity is that surgery helps to get a slender figure in just one or a few days.

• To get a perfect figure by means of prescription diet pills, from 4 up to 12 weeks is required.
• For a significant weight loss by means of over-the-counter diet pills, approximately half a year is required.
• When only diet therapy and regular physical loads are used for weight loss, the duration of weight loss program may reach a few years.

Surgery is a highly effective, but very expensive way of weight loss. Millions of obese people cannot pay surgeon services, so they use RX or OTC diet pills for weight loss.

Obesity and plastic surgeryOne of the best RX diet pills in 2015 can be called Phentermine. In the USA, Phentermine is the most popular drug for weight loss. Despite the fact that the number of overweight and obese Americans increases each year, the sales of Phentermine are gradually reduced in the USA.

The reason for lower demand for Phentermine in the USA is that the FDA has approved several new drugs for the obesity treatment for the last few years.
 

In 2015, the US suppliers of Phentermine have to compete with the suppliers of new anti-obesity drugs, such as Belviq and Qsymia. The manufacturers of new diet pills claim that their weight loss products are safer than Phentermine pills.

However, given the fact that Qsymia and Belviq are sold just a few years, their long-term effects are insufficiently studied. Therefore, many American doctors continue to prescribe to their patients well-studied Phentermine-containing weight loss products.

Duromine effects

Besides that Duromine diet pills suppress appetite, they can influence physiological systems, internal organs and mental health of the person. Reduced appetite, increase in thermogenesis and metabolism are therapeutic effects of Duromine that help significantly to lose weight in just a few weeks.

Apart from therapeutic effects, Duromine can cause side effects including undesired impact on the functions of cardiovascular system.

• If side effects of Duromine do not create a serious threat to health, anti-obesity therapy can be conducted without any restrictions.

• If Duromine causes severe side effects, special precautions can be required during the obesity treatment.

Duromine effects: fertility

PregnancyDuromine pills have been studied for weight loss for over 20 years and their impact on fertility is well studied. The results of studies demonstrate that Duromine does not affect the female reproductive function. Therefore, the chances to become pregnant prior anti-obesity therapy are the same as after the end of using Duromine pills.

Duromine does not affect the sperm morphology and male reproductive function, but can cause erectile dysfunction. Despite the fact that Duromine pills do not affect the male fertility, some men lose the ability to conceive after the start of using them.

If a woman gets pregnant during the drug therapy of obesity, she should stop using Duromine pills and inform the doctor about the pregnancy. To evaluate the Duromine effect on the fetus, the doctor will prescribe the woman a series of diagnostic tests. Only after the results of these tests, the doctor can recommend to keep or terminate the pregnancy.

To terminate pregnancy in the first days after sexual act, emergency hormonal contraception can be used. If a woman taking Duromine finds out she is pregnant a few weeks after sexual act, she should discuss with her treating doctor the optimal method of contraception.

To prevent unwanted pregnancy during the drug therapy of obesity, men and women taking Duromine should use reliable contraception methods.

Duromine effects: teeth

Duromine does not destroy tooth enamel and does not cause tooth decay, but causes dryness in the mouth. Because of saliva deficiency in the oral cavity, dental plaque is very quickly formed on the teeth because of which the diseases of teeth and gums can develop.

In order to prevent undesirable Duromine effects on the teeth health, chewing gum, regular tooth brushing and mouthwashes can be used to stimulate salivation.

Duromine QA

• Can I use Duromine as a replacement by a healthy diet and regular exercise?

No, you cannot. Duromine should be used in the combination with drug-free methods to fight obesity, such as physical activity and a balanced diet.

• How do I learn whether I can use Duromine for the obesity treatment or not?

Duromine can be prescribed only by the doctors who have experience in treating patients with obesity or overweight. Duromine can be prescribed only to patients for whom benefits of using Duromine exceed the potential health risks.

• How to get a prescription for Duromine?

Before writing out a prescription for Duromine, the doctor should learn the current state of the patient and the history of all his diseases. For an objective assessment of mental and physical condition of the patient, a full medical examination may be required.

• Under what conditions can a doctor refuse to write out a prescription for Duromine?

The reason why a doctor may refuse to prescribe Duromine can be one or several risk factors, such as: uncontrolled hypertension, eating disorders (bulimia, anorexia), history of drug or alcohol abuse, pregnancy, planning a surgery requiring general anesthesia, the use of certain groups of drugs (antidepressants, antimigraine agents, MAO inhibitors), glaucoma, history of depression.

• How long should I use Duromine?

Duration of Duromine use depends on the rate of weight loss, presence / absence of side effects, the dynamics of change in the overall health. Regardless of obesity severity, the duration of Duromine use may vary from two weeks up to three months.

• What Duromine doses are used for the obesity treatment?

A Duromine 15mg capsule is the most prescribed daily dose for overweight patients with BMI of 25 to 29.9. The most prescribed dose of Duromine for obese patients with BMI of 30 and higher is 30mg. The maximum dose of Duromine 40mg is prescribed in rare cases.

• What side effects may occur after Duromine use?

Regardless of Duromine dose, a patient may experience dry mouth, dizziness, headache, gastric disorders, hypertension and other side effects. When the maximum dose of Duromine 40mg is used regularly, the risk of drug dependence increases.

• Does the weight increase after I stop taking Duromine?

After the end of medical therapy of obesity, body fat percentage can again start to increase. To prevent obesity, you should continue to adhere to a hypocaloric diet and to be physically active after the end of Duromine use.

• Can a doctor prescribe Duromine to children or adolescents?

In Australia, Duromine was approved as an obesity treatment in adolescents from 12 years and older. Children under 12 years did not participate in clinical trials of Duromine. It should be noted that in the USA, Phentermine-containing drugs (including Adipex) are not prescribed for the obesity treatment in adolescents under 16 years old.

• Where Duromine pills are manufactured?

Duromine 15mg, 30mg and 40mg pills are manufactured in Australia and imported to several countries, such as New Zealand, China (Hong Kong), Singapore, South African Republic. In Australia, Duromine pills were approved as an obesity treatment in 1991.

• What drugs can be used as an alternative to Duromine?

Dozens of drugs containing anorexigenic agent, Phentermine are available at the U.S. market of weight loss products. Most of these drugs are sold under the proprietary name Phentermine Hydrochloride.

In addition, Phentermine-containing diet pills are available at the U.S. pharmacies under the proprietary trademarks Suprenza and Adipex. Just as in Australia, in the USA Phentermine-containing diet pills are sold by prescription only.