Saxenda contraindications

The list of Saxenda contraindications includes just a few diseases and conditions. Saxenda slimming drug should not be prescribed to overweight and obese men and women with:

• multiple endocrine neoplasia type 2 (MEN 2)
• medullary thyroid cancer (MTC) or family history of MTC
• allergy to anorexigenic agent – Liraglutide or inactive ingredients of Saxenda.

Children, adolescents under 18 years and pregnant women did not participate in clinical trials of Saxenda. Therefore, these groups of patients should be prescribed with alternative drugs for the obesity treatment instead of Saxenda.

Besides the list of contraindications, Product Monograph (Highlights of Prescribing Information) for Saxenda includes the list of cautions.

Saxenda cautions

Saxenda injections should not be prescribed to patients, who are taking or planning to take other drugs included in the pharmacological group of glucagon-like peptide-1 (GLP-1) receptor agonists, such as:

• Albiglutide (Eperzan)
• Dulaglutide (Trulicity)
• Lixisenatide (Lyxumia)
• Exenatide (Bydureon, Byetta)

Moreover, Saxenda should not be used in the combination with insulin and other prescription or over-the-counter weight loss products.

saxendaIf inflammation of pancreas occurred and pancreatitis was diagnosed during medical therapy of obesity, Saxenda use should be stopped. The main symptom of pancreatitis is severe abdominal pain.

Saxenda can cause a significant reduction of blood sugar level. Therefore, after the monitoring of blood glucose parameters, diabetic patients taking Saxenda may require the adjustment of daily doses of hypoglycemic drugs.

Some patients using Saxenda may develop gallstone disease. Data of clinical studies is insufficient to claim that gallstone disease is caused by Saxenda.

Nevertheless, if problems with gall bladder or bile ducts occur, it is necessary to stop using Saxenda and diagnose the cause of gallstone disease symptoms.

During clinical studies, it was recorded individual cases of thyroid cancer. However, a causal relationship between Saxenda use and thyroid cancer was not established. Nevertheless, the signs of thyroid cancer require an immediate cancellation of Saxenda. The main signs of thyroid cancer are increase in the size and mass of the neck, hoarseness, reduction in the frequency and depth of breathing, inflammation of the esophagus.

Saxenda may cause a slight increase in heart rate. Thus, obese patients with tachycardia require a regular monitoring of heart rate after the start of Saxenda use.

Saxenda can affect kidney functions. Therefore, patients with renal insufficiency should take Saxenda with caution.

In 0.2 % obese patients, treated with Saxenda during clinical studies, had suicidal thoughts and signs of depression. If unusual behavior or signs of anxiety disorder are observed after the start of Saxenda use, be sure to inform your treating physician.

Duromine effects on pregnancy

About 80% of pregnant women take medications that can cross the placenta and affect the fetal development. Some medications are prescribed during pregnancy to stimulate a normal fetal development. However, majority of medicines used during pregnancy are necessary to maintain the health of the pregnant woman.

Medications that have a negative effect on the fetal development are contraindicated during pregnancy. However, only in individual cases, the use of potentially dangerous medications during pregnancy is allowed. Herewith, medical therapy is conducted under the constant supervision of the treating doctor.

Duromine effects on pregnancy

Duromine is one of the few medications, which is contraindicated in pregnant women, however in rare cases it is used during pregnancy.

Pregnant women take Duromine only in the cases if overweight or obesity creates serious risks for their health or fetal health.

According to the Australian classification of potential risks to pregnant women, Duromine is included in B2 category. In the USA, Phentermine-containing medications are included in X category.

It should be noted that at various stages of pregnancy, Duromine has different risks to the fetus.

Duromine poses the greatest risk to the fetus in the first trimester of pregnancy when embryonic cells are actively dividing, and physiological systems and organs are formed and rapidly developed.

  • During the embryonic period, Duromine can cause birth defects that are the main cause of infant mortality in Australia and other developed countries.
  • After the end of the embryonic period, Duromine may cause developmental delay and functional immaturity of the fetal organs.

Potential risks of Duromine for mother and fetus depend both on the pregnancy trimester and on the dose used. The higher Duromine dose is, the higher the risk of disruption of the normal development of the fetus.

Herewith, the use of the maximum daily dose of Duromine between fertilization and implantation of the egg can cause miscarriage.

Women of childbearing age using Duromine should remember that during the first two-three weeks after conception they might not know about their pregnancy.

Therefore, in order to prevent the birth of a child with congenital defects, sexually active women should:

  • Take a pregnancy test and verify the absence of pregnancy before using Duromine.
  • Use reliable contraceptive methods during Duromine use.

If before the drug therapy of obesity, the test confirmed pregnancy, you should discuss with your doctor the possibility of using over-the-counter weight loss supplements, absolutely safe for the health of the mother and unborn child.

Duromine effects

Besides that Duromine diet pills suppress appetite, they can influence physiological systems, internal organs and mental health of the person. Reduced appetite, increase in thermogenesis and metabolism are therapeutic effects of Duromine that help significantly to lose weight in just a few weeks.

Apart from therapeutic effects, Duromine can cause side effects including undesired impact on the functions of cardiovascular system.

• If side effects of Duromine do not create a serious threat to health, anti-obesity therapy can be conducted without any restrictions.

• If Duromine causes severe side effects, special precautions can be required during the obesity treatment.

Duromine effects: fertility

PregnancyDuromine pills have been studied for weight loss for over 20 years and their impact on fertility is well studied. The results of studies demonstrate that Duromine does not affect the female reproductive function. Therefore, the chances to become pregnant prior anti-obesity therapy are the same as after the end of using Duromine pills.

Duromine does not affect the sperm morphology and male reproductive function, but can cause erectile dysfunction. Despite the fact that Duromine pills do not affect the male fertility, some men lose the ability to conceive after the start of using them.

If a woman gets pregnant during the drug therapy of obesity, she should stop using Duromine pills and inform the doctor about the pregnancy. To evaluate the Duromine effect on the fetus, the doctor will prescribe the woman a series of diagnostic tests. Only after the results of these tests, the doctor can recommend to keep or terminate the pregnancy.

To terminate pregnancy in the first days after sexual act, emergency hormonal contraception can be used. If a woman taking Duromine finds out she is pregnant a few weeks after sexual act, she should discuss with her treating doctor the optimal method of contraception.

To prevent unwanted pregnancy during the drug therapy of obesity, men and women taking Duromine should use reliable contraception methods.

Duromine effects: teeth

Duromine does not destroy tooth enamel and does not cause tooth decay, but causes dryness in the mouth. Because of saliva deficiency in the oral cavity, dental plaque is very quickly formed on the teeth because of which the diseases of teeth and gums can develop.

In order to prevent undesirable Duromine effects on the teeth health, chewing gum, regular tooth brushing and mouthwashes can be used to stimulate salivation.

Obesity consequences for women’s health

obese-womanBesides that obesity reduces social activity and quality of life, it may cause serious risk to human health. Overweight affects almost all systems, functions and vital organs. Therefore, during weight gain, the risk of several diseases increases.

Obesity in men is as dangerous as in women. Herewith, excess weight can cause diseases and conditions in women that cannot occur in men.

One of the most common obesity consequences for the female body is menstrual disorder. In obesity, a key reason for menstrual disorder is that hypothalamus abnormally functions in obese women.

Because of hypothalamic dysfunction, secretion of gonadotropic hormones is disturbed and functions of sexual glands are suppressed. In obese women and girls, as a result of such changes:

• Term of menarche and menopause may change
• Irregular menstruation may occur
• Hypomenorrhea and amenorrhea may develop
• A risk of primary and secondary infertility can be increased

In adult women suffering from obesity, menstrual disorders are diagnosed 6 times more often than in healthy women. Herewith, in obese women the risk of primary infertility is two times higher than in women with normal body weight.

Special attention should be paid to the fact that the chances of pregnancy are not only reduced, but also the risks during pregnancy, childbirth and the postpartum period are increased because of overweight and obesity. Therefore, when planning a pregnancy, obese women need to do everything possible to reduce and to normalize their weight.

Besides menstrual disorders, infertility and pregnancy complications, obesity may promote the development of polycystic ovary syndrome (PCOS). The main reason for PCOS in obesity is a disorder of estrogens and androgens metabolism in fat cells (adipocytes).

To combat obesity and reduce the associated risk factors, women should necessarily use non-drug methods of weight loss, including diet therapy and adequate physical activity. These methods of obesity treatment may be supplemented by:

• Drug therapy (use of RX or OTC diet pills)
• Physiotherapy procedures (massage, reflexology, acupuncture, hydrotherapy)
• Psychotherapy (cognitive behavioral therapy, neuro-linguistic programming)
• Surgery (liposuction, gastric banding)

It should be noted that many women manage to lose weight only by means of diet and regular physical exercise. However, if these methods of dealing with obesity do not provide a significant weight loss, they should be supplemented by one or several alternative ways of losing weight.

Duromine and obesity treatment in children

Overweight children using Duromine need a regular medical supervision. The purpose of this supervision is to support the motivation to lose weight and to prevent obesity complications. In addition, the doctor’s supervision helps to reveal potentially dangerous side effects that Duromine may cause timely.

Obese children with formed dietary stereotypes are better to use Duromine away from the home environment. To that home environment does not cause to mind any irrational dietary habits, the doctor can recommend to start an anti-obesity treatment in the clinic.

Being under a constant supervision of the doctor, a child can keep the hypocaloric diet and Duromine dose regimen much easier than on his own. The purpose of early anti-obesity treatment in the clinic is:

• To reduce the body mass by 5-10% from the initial weight
• To reduce the risk of obesity complications
• To increase tolerance to physical exertion

Many doctors hospitalize a child only if he is diagnosed a severe obesity or if he has some obesity complications. In excess weight or moderate obesity, a child is recommended to use non-medical weight loss methods, such as:

• Change the dietary habits
• Increase physical activity
• Refuse from excessive use of carbs and fats
• Increase the number of meals and reduce the servings

kid-fatIf non-medical anti-obesity treatment did not give a significant weight loss, a child is usually prescribed with a minimal daily dose of Duromine 15mg.

Starting the therapy with Duromine 15mg pills, a child should continue using non-medical methods of fighting obesity. Because if he does not keep a balanced, hypocaloric diet and does not do regular physical exercises, he can never lose weight quickly.

A successful weight loss is only possible if Duromine is used along with some steps:

• Normalization of eating behavior
• Increase in physical activity
• Improvement of carbohydrate and lipid metabolism

In Australia, Duromine is approved for obesity treatment in children older than 12 years. Regardless of the severity of a childhood obesity, it is recommended to initiate the drug treatment course with a minimal daily dose of Duromine 15mg. Later, Duromine dose for children can be increased up to 30mg. Overweight children under 11 years old (inclusive) have never participated in Duromine clinical trials.

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Fast food in schools of Poland

In October 2014, a new law was passed restricting to sell fast food in school institutions of Poland. This law will come into force in 2015.

• The reason this law was passed lies in the increased number of children suffering from obesity.
• The main purpose of banning fast food in schools is prevention of obesity in children and teens.

In the beginning of the next year, it is planned to distribute at schools of Poland only those foods that were approved by the Ministry of Health.

Both employees of the Ministry of Health, school principals and pupils’ parents will make up the list of foods that are allowed for sale in schools.

Foods, prohibited for sale in school institutions, will be missing in the building itself as well as the whole school grounds area.

Key principles of diet therapy in childhood

The main principle of diet therapy is to reduce the energy value of food and to achieve a negative energy balance.

More optimal therapeutic nutrition for children and adolescents with obesity is to use classic hypocaloric diet. A balanced diet for children has practically no contraindications, and its duration is not limited.

Standard diet for obese children is usually ineffective. This category of patients requires the maximum personification of diet, taking into account:

• The presence or absence of complications
• Individual food preferences
• The expected duration of diet therapy
• Individual indicators of nutritional status

kideatingIn the first days of treatment, it is necessary to reduce the calorie intake, because the diet of obese children usually contains an excess amount of nutrients.

At the main stage of the treatment, the diet should be hypocaloric with low content of carbohydrates and fats of animal origin. The amount of protein in the diet should correspond to the age norm, but calorie reduction is achieved by decreasing the content of carbohydrates and partly fats.

• The amount of fat in the diet should be reduced by 10-15% (animal fats are replaced by the vegetable ones).
• Readily soluble and quickly digestible sugars should be completely excluded from the diet, and the consumption of refined sugars should be limited.

One of the simplest and most effective ways to reduce the energy value of the diet is to decrease the consumption of sugary drinks or complete refusal of them.

Children should consume foods high in fiber, which promotes rapid saturation and acceleration of the passage of food through the intestines.

Diet therapy in childhood should be prolonged (at least 6-12 months), but herewith the diet:

• Should provide a sufficient saturation
• Should not violate physical and mental development
• Should not prevent normal physical activities

A significant disadvantage of traditional hypocaloric diet is the difficulty to adhere to it because of the feeling of hunger (especially at the early stages). In the absence of sufficient motivation, obese children can be:

• Recommended regular consultations of psychologist and nutritionist
• Prescribed with over-the-counter or Rx weight loss medications

child-obesityAustralian adolescents suffering from obesity can be prescribed with Rx appetite suppressant – Duromine. This medication can be prescribed to overweight and obese children who are over 12 years old.

From the first day of using Duromine medication, the child will be easier to comply with hypocaloric diet. Herewith, the child will be able to reduce both the amount and frequency of food intakes.

Duromine helps to reduce hunger and to change eating behavior. However, do not forget that a child needs help of his parents, nutritionists and (or) psychotherapists for the formation of sustained motivation to eat healthy food.

In addition to the use of Duromine appetite suppressant, healthy diet, psychotherapeutic help and parental support, obese child needs to be physically active.

Level of physical activity should appropriate to the child’s age and should not cause severe emotional or physical discomfort. When using Duromine diet pills, the child can develop high blood pressure. Therefore, daily physical activity should be mild or moderate.

Intense physical exercise is not recommended neither for children taking Duromine, nor for adults. Cardiovascular effects are some of the most common side effects of Duromine. Therefore, children and adults with symptoms or history of cardiovascular diseases should take Duromine only under the constant supervision of the treating physician.

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Diet for overweight children

Therapeutic diet for obese children and teenagers must be maximally varied, including all the main food groups:

• Meat and seafood
• Fish and fish products
• milk and dairy
• eggs
• fruit and vegetables
• bread and bakery products
• cereals, pasta and beans
• dietary fat
• sweets and confectionary (strictly limited)

Only a varied diet can provide a child’s body with essential and nonessential nutrients. The most important points of diet therapy for children are:

• restriction of total fat in the diet
• optimization of fatty and acid composition in the diet
• reduction of saturated fat in the diet
• increase in consumption of polyunsaturated fatty acids

The total amount of fat in the diet can be reduced by adding foods with medium amount of fat into the diet.

1. Obese children should drink milk and fermented milk products (kefir, yogurt) containing 2.5% fat maximum.
2. Parents should cook meat dishes for their overweight children from fat-free beef, poultry and rabbit.
3. Dietary fat from the daily diet of an obese child should consist of vegetable fat at least by 30%.
4. An important source of polyunsaturated fatty acids in a child’s diet should be fish (herring, salmon and trout).

Boy-EatingThe important point of diet for overweight children is to limit the consumption of salt. Physiological need of a child’s body is just 5 g of salt per day. Therefore, you should cook foods without adding salt into it and limit foods that are high in salt (canned meat and fish, cheese and sausages).

In addition, children’s diet should contains different fruit and vegetables with plenty of important nutrients. Consumption of sufficient amount of fruit and vegetables helps to:

• Absorb and digest other products
• Normalize intestinal peristalsis
• Reduce the blood cholesterol
• Normalize bile secretion

Overweight children are not recommended to eat fried food. Thus, they need to be taught to eat boiled and steamed food, cooked with no butter and oil, or with minimal amount of dietary fat.

One of the universal components of the weight loss program is monitoring and records of consumed food. Once the diet therapy was started, it is necessary to keep a dietary diary, recording the number of calories and level of physical activity. Actually, both children and parents can keep the dietary diary.

Analyzing data from the diary, you can see some unexpected factors that help to increase the effectiveness of weight loss program.

School-age children, who suffer from obesity, can be prescribed 1 fasting day a week in addition to hypocaloric diet. The daily caloric value during such days must not exceed 1000 kcal.

Childhood obesity in the UK

In 2013, the number of British children under 12 years old, suffering from overweight has increased by 12%.

Within the last three years, in England, Scotland and Wales there were registered 183 children under 11 years old whose body weight was over 100 kilograms. The heaviest child’s weight in the UK is 147 kg.

Herewith, the number of obese people of any age group in England has decreased, except for:

• Children under 16 years old
• Elderly over 65 years old

CHILDHOOD-OBESITYThe increased number of overweight children and elderly British may be caused by the fact that many slimming medicines are contraindicated for these age groups.

For instance, one prescription appetite suppressant called Ionamin (Phentermine) is contraindicated for children under 12 years old, while the prescription fat blocker called Beacita (Orlistat) is contraindicated to children under 16 years old. Other than that, Ionamin and Beacita slimming medicines are contraindicated for elderly people over 65 years old.

Today, about 26% of British people have excess weight problems, and obesity is called one of the main medical issues of the nation. According to prognosis of British doctors, over 50% of UK people will be suffering from obesity by 2050.

Antibiotics and obesity

American scientists concluded that children under two years old are at high risk of obesity if they use antibiotics. The survey that was carried out between 2001 and 2013 revealed that 33% of children, taking potent medications, have suffered from overweight by four years of age.

The new medical study has shown a close connection between antibiotics used in children under two years old and obesity that developed in the future. Dr. Charles Bailey at the Children’s Hospital of Philadelphia (an author of new method) analyzed along with his colleagues histories of children’s diseases during the first five years of their life.

Antibiotics-and-obesityThe study took place from 2001 to 2013. Almost 70% of children aged 0 to 2 years were taking antibiotics. By that time, 23% of them were suffering from obesity. By the age three and four, this number increased up to 30% and 33% respectively, according to The Fox News.

Scientists could not find out whether medications were the cause of obesity, as stated by Dr. Bailey. One of the most probable hypothesis is that antibiotics destroy bacteria in the stomach. At this condition, the body preferably needs to gain weight.

Medications can change the taste of foods or cause other unwanted effects. Sometimes doctors just have to prescribe children antibiotics in early age, when their own immune system is still undeveloped.

However, doctors accept the probability of that obesity is caused by not antibiotics themselves, but most likely, by diseases that are cured with these drugs. Besides, heredity and food that children eat may cause overweight as well.

It is noteworthy that this was not the only study, proving the connection between antibiotics and obesity. Thus, a group of scientists from The New York University led by Dr. Martin Blaser made an experiment, which has shown that children, who were taking antibiotics during the first few weeks of their life, have had a slow metabolism, resulting in a rapid weight gain.

The antibiotics abuse can also cause asthma, allergy or even diabetes. Dr. Blaser believes that it is very important to reduce the usage of antibiotics, as well as carry out diagnostics that might help the doctors determine the cause of infection more precisely.